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Mouse Anti-SIVA1 Recombinant Antibody (CBXS-3851) (CBMAB-S1121-CQ)

This product is a mouse antibody that recognizes SIVA1. The antibody CBXS-3851 can be used for immunoassay techniques such as: IF, WB.
See all SIVA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3851
Antibody Isotype
IgG1
Application
IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SIVA1 Apoptosis Inducing Factor
Introduction
This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.
Entrez Gene ID
10572
UniProt ID
O15304
Alternative Names
SIVA1 Apoptosis Inducing Factor; CD27BP; SIVA; Apoptosis Regulatory Protein Siva; CD27-Binding (Siva) Protein; CD27-Binding Protein; Siva-1; Siva-2;
Function
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Biological Process
Biological Process activation-induced cell death of T cellsIDA:HGNC-UCL
Biological Process extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process intrinsic apoptotic signaling pathwayIDA:BHF-UCL
Biological Process negative regulation of NF-kappaB transcription factor activityIDA:HGNC-UCL
Biological Process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayIDA:BHF-UCL
Cellular Location
Cytoplasm
Nucleus
In the nucleus, accumulates in dot-like structures.
PTM
Phosphorylated by ABL2/ARG in response to oxidative stress.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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