Mouse Anti-SIVA1 Recombinant Antibody (CBXS-4485) (CBMAB-S1727-CQ)

Name: Mouse Anti-SIVA1 Recombinant Antibody (CBXS-4485)
SKU: CBMAB-S1727-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBXS-4485

Application

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SIVA1 Apoptosis Inducing Factor

Introduction

This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.

Entrez Gene ID

10572

UniProt ID

O15304

Alternative Names

SIVA1 Apoptosis Inducing Factor; CD27BP; SIVA; Apoptosis Regulatory Protein Siva; CD27-Binding (Siva) Protein; CD27-Binding Protein; Siva-1; Siva-2;

Function

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.

Biological Process

Biological Process activation-induced cell death of T cellsIDA:HGNC-UCL
Biological Process extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process intrinsic apoptotic signaling pathwayIDA:BHF-UCL
Biological Process negative regulation of NF-kappaB transcription factor activityIDA:HGNC-UCL
Biological Process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayIDA:BHF-UCL

Cellular Location

Cytoplasm
Nucleus
In the nucleus, accumulates in dot-like structures.

PTM

Phosphorylated by ABL2/ARG in response to oxidative stress.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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