SIVA1

This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.

SIVA1 Apoptosis Inducing Factor

Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.

Biological Process activation-induced cell death of T cellsIDA:HGNC-UCL
Biological Process extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process intrinsic apoptotic signaling pathwayIDA:BHF-UCL
Biological Process negative regulation of NF-kappaB transcription factor activityIDA:HGNC-UCL
Biological Process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayIDA:BHF-UCL

Cytoplasm
Nucleus
In the nucleus, accumulates in dot-like structures.

Phosphorylated by ABL2/ARG in response to oxidative stress.