SIVA1

This gene encodes a protein with an important role in the apoptotic (programmed cell death) pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen cytoplasmic tail binds to the N-terminus of this protein. Two alternatively spliced transcript variants encoding distinct proteins have been described.
Full Name
SIVA1 Apoptosis Inducing Factor
Function
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.
Biological Process
Biological Process activation-induced cell death of T cellsIDA:HGNC-UCL
Biological Process extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process intrinsic apoptotic signaling pathwayIDA:BHF-UCL
Biological Process negative regulation of NF-kappaB transcription factor activityIDA:HGNC-UCL
Biological Process positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayIDA:BHF-UCL
Cellular Location
Cytoplasm
Nucleus
In the nucleus, accumulates in dot-like structures.
PTM
Phosphorylated by ABL2/ARG in response to oxidative stress.
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Anti-SIVA1 antibodies

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Mouse Anti-SIVA1 Recombinant Antibody (CBXS-2302) (CBMAB-S5064-CQ)

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Target: SIVA1
Host: Mouse
Specificity: Human
Clone: CBXS-2302
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SIVA1 Recombinant Antibody (CBXS-4608) (CBMAB-S1848-CQ)

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Target: SIVA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4608
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-SIVA1 Recombinant Antibody (CBXS-4541) (CBMAB-S1781-CQ)

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Target: SIVA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4541
Application*: WB
Datasheet SDS

Mouse Anti-SIVA1 Recombinant Antibody (CBXS-4485) (CBMAB-S1727-CQ)

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Target: SIVA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4485
Application*: WB
Datasheet SDS

Mouse Anti-SIVA1 Recombinant Antibody (CBXS-4406) (CBMAB-S1648-CQ)

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Target: SIVA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-4406
Application*: WB
Datasheet SDS

Mouse Anti-SIVA1 Recombinant Antibody (CBXS-4189) (CBMAB-S1442-CQ)

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Target: SIVA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4189
Application*: WB
Datasheet SDS

Mouse Anti-SIVA1 Recombinant Antibody (CBXS-4004) (CBMAB-S1265-CQ)

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Target: SIVA1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4004
Application*: WB
Datasheet SDS

Mouse Anti-SIVA1 Recombinant Antibody (CBXS-3947) (CBMAB-S1210-CQ)

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Target: SIVA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3947
Application*: WB
Datasheet SDS

Mouse Anti-SIVA1 Recombinant Antibody (CBXS-3851) (CBMAB-S1121-CQ)

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Target: SIVA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-3851
Application*: IF, WB
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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