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Mouse Anti-SLC18A2 Recombinant Antibody (CBXS-5943) (CBMAB-S0792-CQ)

This product is a mouse antibody that recognizes SLC18A2. The antibody CBXS-5943 can be used for immunoassay techniques such as: FC, IF, IHC, WB.
See all SLC18A2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Rat, Monkey
Clone
CBXS-5943
Antibody Isotype
IgG1
Application
FC, IF, IHC, WB

Basic Information

Immunogen
A protein expressed in 293T cell transfected with human SLC18A2 expression vector
Specificity
Human, Dog, Rat, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 18 Member A2
Introduction
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).
Entrez Gene ID
Human6571
Monkey701133
Rat25549
Dog486908
UniProt ID
HumanQ05940
MonkeyG7N180
RatQ01827
DogA0A8I3QQP1
Alternative Names
Solute Carrier Family 18 Member A2; Solute Carrier Family 18 (Vesicular Monoamine Transporter), Member 2; Solute Carrier Family 18 Member 2; Vesicular Amine Transporter 2; Monoamine Transporter; VMAT2; SVMT; VAT2;
Function
Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed:23363473).
Requisite for vesicular amine storage prior to secretion via exocytosis.
Biological Process
Biological Process aminergic neurotransmitter loading into synaptic vesicleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process dopamine transportManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process locomotory behaviorIEA:Ensembl
Biological Process monoamine transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of reactive oxygen species biosynthetic process1 PublicationNAS:ParkinsonsUK-UCL
Biological Process neurotransmitter loading into synaptic vesicleManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process neurotransmitter transportTAS:Reactome
Biological Process post-embryonic developmentIEA:Ensembl
Biological Process response to amphetamineIEA:Ensembl
Biological Process response to toxic substanceIEA:Ensembl
Biological Process sequestering of neurotransmitter1 PublicationNAS:ParkinsonsUK-UCL
Cellular Location
Cytoplasmic vesicle membrane
Involvement in disease
Parkinsonism-dystonia 2, infantile-onset (PKDYS2):
An autosomal recessive disorder characterized by infantile onset of abnormal movements, including parkinsonism, dystonia, and poor fine motor skills, as well as autonomic dysfunction, including abnormal sweating, cold extremities, and poor sleep. Some patients have variable degrees of developmental delay.
Topology
Cytoplasmic: 1-20
Helical: 21-41
Lumenal: 42-129
Helical: 130-150
Cytoplasmic: 151-159
Helical: 160-180
Lumenal: 181-189
Helical: 190-210
Cytoplasmic: 211-219
Helical: 220-242
Lumenal: 243-248
Helical: 249-271
Cytoplasmic: 272-291
Helical: 292-311
Lumenal: 312-328
Helical: 329-352
Cytoplasmic: 353-357
Helical: 358-378
Lumenal: 379-389
Helical: 390-410
Cytoplasmic: 411-414
Helical: 415-435
Lumenal: 436-440
Helical: 441-462
Cytoplasmic: 463-514
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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