Mouse Anti-SLC18A2 Recombinant Antibody (CBXS-5967) (CBMAB-S0814-CQ)

Name: Mouse Anti-SLC18A2 Recombinant Antibody (CBXS-5967)
SKU: CBMAB-S0814-CQ
Rating: 5 (1 reviews)

See all SLC18A2 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-5967

Application

FC, IF, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 1% BSA, 50% glycerol

Preservative

0.02% sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Solute Carrier Family 18 Member A2

Introduction

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).

Entrez Gene ID

6571

UniProt ID

Q05940

Alternative Names

Solute Carrier Family 18 Member A2; Solute Carrier Family 18 (Vesicular Monoamine Transporter), Member 2; Solute Carrier Family 18 Member 2; Vesicular Amine Transporter 2; Monoamine Transporter; VMAT2; SVMT; VAT2;

Function

Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles (PubMed:23363473).
Requisite for vesicular amine storage prior to secretion via exocytosis.

Biological Process

Biological Process aminergic neurotransmitter loading into synaptic vesicleManual Assertion Based On ExperimentIBA:GO_Central
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process dopamine transportManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process locomotory behaviorIEA:Ensembl
Biological Process monoamine transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of reactive oxygen species biosynthetic process1 PublicationNAS:ParkinsonsUK-UCL
Biological Process neurotransmitter loading into synaptic vesicleManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process neurotransmitter transportTAS:Reactome
Biological Process post-embryonic developmentIEA:Ensembl
Biological Process response to amphetamineIEA:Ensembl
Biological Process response to toxic substanceIEA:Ensembl
Biological Process sequestering of neurotransmitter1 PublicationNAS:ParkinsonsUK-UCL

Cellular Location

Cytoplasmic vesicle membrane

Involvement in disease

Parkinsonism-dystonia 2, infantile-onset (PKDYS2):
An autosomal recessive disorder characterized by infantile onset of abnormal movements, including parkinsonism, dystonia, and poor fine motor skills, as well as autonomic dysfunction, including abnormal sweating, cold extremities, and poor sleep. Some patients have variable degrees of developmental delay.

Topology

Cytoplasmic: 1-20
Helical: 21-41
Lumenal: 42-129
Helical: 130-150
Cytoplasmic: 151-159
Helical: 160-180
Lumenal: 181-189
Helical: 190-210
Cytoplasmic: 211-219
Helical: 220-242
Lumenal: 243-248
Helical: 249-271
Cytoplasmic: 272-291
Helical: 292-311
Lumenal: 312-328
Helical: 329-352
Cytoplasmic: 353-357
Helical: 358-378
Lumenal: 379-389
Helical: 390-410
Cytoplasmic: 411-414
Helical: 415-435
Lumenal: 436-440
Helical: 441-462
Cytoplasmic: 463-514

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-SLC18A2 Recombinant Antibody (CBXS-5967)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SLC18A2 Recombinant Antibody (10C11) (CAT#: CBMAB-V0119-LY)

Mouse Anti-SLC18A2 Recombinant Antibody (CBXS-5943) (CAT#: CBMAB-S0792-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry