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Mouse Anti-SLC24A1 Recombinant Antibody (1E12) (CBMAB-A8189-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1E12
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SLC24A1 (NP_004718, 162 a.a. ~ 268 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
Introduction
SLC24A1 belongs to a family of potassium-dependent sodium/calcium exchangers. Members of this family have 2 large hydrophilic loops and 2 sets of multiple transmembrane-spanning segments (Schnetkamp, 2004 [PubMed 14770312]).[supplied by OMIM
Entrez Gene ID
9187
UniProt ID
O60721
Alternative Names
HsT17412; KIAA0702; NCKX; NCKX1; RODX
Function
Calcium, potassium:sodium antiporter that transports 1 Ca2+ and 1 K+ in exchange for 4 Na+ (PubMed:26631410).
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness (PubMed:20850105).
Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (PubMed:20850105).
Biological Process
Biological Process calcium ion import across plasma membraneBy SimilarityISS:ARUK-UCL
Biological Process calcium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process calcium ion transport1 PublicationNAS:UniProtKB
Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process ion transportTAS:Reactome
Biological Process long-term synaptic depressionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process long-term synaptic potentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process response to light intensity1 PublicationNAS:UniProtKB
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process visual perception1 PublicationNAS:UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Night blindness, congenital stationary, 1D (CSNB1D):
An autosomal recessive form of congenital stationary night blindness, a non-progressive retinal disorder characterized by impaired night vision. CSNB1D is characterized by a Riggs type of electroretinogram (proportionally reduced a- and b-waves). Patients have visual acuity within the normal range and no symptoms of myopia and/or nystagmus.
PTM
The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration.
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For research use only. Not intended for any clinical use.

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