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Mouse Anti-SLC24A1 Recombinant Antibody (CBXS-2758) (CBMAB-S5509-CQ)

This product is a mouse antibody that recognizes SLC24A1. The antibody CBXS-2758 can be used for immunoassay techniques such as: ELISA, WB.
See all SLC24A1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2758
Application
ELISA, WB

Basic Information

Immunogen
SLC24A1 (NP_004718, 162aa-268aa) partial recombinant protein with GST tag
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
Introduction
This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Entrez Gene ID
9187
UniProt ID
O60721
Alternative Names
Solute Carrier Family 24 Member 1; Solute Carrier Family 24 (Sodium/Potassium/Calcium Exchanger), Member 1; Na(+)/K(+)/Ca(2+)-Exchange Protein 1; NCKX1; Sodium/Potassium/Calcium Exchanger 1; Retinal Rod Na+/Ca+/K+ Exchanger; Retinal Rod Na-Ca+K Exchanger;
Function
Calcium, potassium:sodium antiporter that transports 1 Ca2+ and 1 K+ in exchange for 4 Na+ (PubMed:26631410).
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness (PubMed:20850105).
Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (PubMed:20850105).
Biological Process
Biological Process calcium ion import across plasma membraneBy SimilarityISS:ARUK-UCL
Biological Process calcium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process calcium ion transport1 PublicationNAS:UniProtKB
Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process ion transportTAS:Reactome
Biological Process long-term synaptic depressionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process long-term synaptic potentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process response to light intensity1 PublicationNAS:UniProtKB
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process visual perception1 PublicationNAS:UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Night blindness, congenital stationary, 1D (CSNB1D):
An autosomal recessive form of congenital stationary night blindness, a non-progressive retinal disorder characterized by impaired night vision. CSNB1D is characterized by a Riggs type of electroretinogram (proportionally reduced a- and b-waves). Patients have visual acuity within the normal range and no symptoms of myopia and/or nystagmus.
PTM
The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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