Human SLC24A1 ELISA Kit (V2LY-0626-LY3165)

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Tested Data
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Basic Information

Sensitivity
0.021 ng/mL
Detection Range
0.05-20 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
121.4 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
Function
Calcium, potassium:sodium antiporter that transports 1 Ca2+ and 1 K+ in exchange for 4 Na+ (PubMed:26631410).
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness (PubMed:20850105).
Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation (PubMed:20850105).
Biological Process
Biological Process calcium ion import across plasma membraneBy SimilarityISS:ARUK-UCL
Biological Process calcium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process calcium ion transport1 PublicationNAS:UniProtKB
Biological Process cellular calcium ion homeostasisManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process ion transportTAS:Reactome
Biological Process long-term synaptic depressionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process long-term synaptic potentiationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process potassium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process response to light intensity1 PublicationNAS:UniProtKB
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process visual perception1 PublicationNAS:UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Night blindness, congenital stationary, 1D (CSNB1D):
An autosomal recessive form of congenital stationary night blindness, a non-progressive retinal disorder characterized by impaired night vision. CSNB1D is characterized by a Riggs type of electroretinogram (proportionally reduced a- and b-waves). Patients have visual acuity within the normal range and no symptoms of myopia and/or nystagmus.
PTM
The uncleaved signal sequence is required for efficient membrane targeting and proper membrane integration.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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