Rabbit Anti-SLC25A12 Recombinant Antibody (CBXS-1417) (CBMAB-S4275-CQ)

Name: Rabbit Anti-SLC25A12 Recombinant Antibody (CBXS-1417)
SKU: CBMAB-S4275-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXS-1417

Application

WB, IHC-P

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

0.3 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Solute Carrier Family 25 Member 12

Introduction

This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene.

Entrez Gene ID

Human	8604
Mouse	78830
Rat	362145

UniProt ID

Human	O75746
Mouse	Q8BH59
Rat	F1LX07

Alternative Names

Solute Carrier Family 25 Member 12; Solute Carrier Family 25 (Mitochondrial Carrier, Aralar), Member 12; Solute Carrier Family 25 (Aspartate/Glutamate Carrier), Member 12; Mitochondrial Aspartate Glutamate Carrier 1; Calcium Binding Mitochondrial Carrier Superfamily Member Aralar1; Calcium-Binding Mitochondrial Carrier Protein Aralar1;

Function

Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575).
Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871).

Biological Process

Biological Process aspartate family amino acid metabolic processTAS:Reactome
Biological Process aspartate transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process gluconeogenesisTAS:Reactome
Biological Process glutamate biosynthetic processIEA:Ensembl
Biological Process L-glutamate transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process malate-aspartate shuttleManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of glucose catabolic process to lactate via pyruvateIEA:Ensembl
Biological Process positive regulation of ATP biosynthetic processIEA:Ensembl
Biological Process positive regulation of glucose metabolic processIEA:Ensembl
Biological Process positive regulation of myelinationIEA:Ensembl
Biological Process response to calcium ionManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Mitochondrion inner membrane

Involvement in disease

Developmental and epileptic encephalopathy 39 (DEE39):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE39 is characterized by global hypomyelination of the central nervous system, with the gray matter appearing relatively unaffected. Inheritance is autosomal recessive.

Topology

Mitochondrial intermembrane: 2-329
Helical: 330-347
Mitochondrial matrix: 348-390
Helical: 391-410
Mitochondrial intermembrane: 411-433
Helical: 434-447
Mitochondrial matrix: 448-482
Helical: 483-502
Mitochondrial intermembrane: 503-521
Helical: 522-539
Mitochondrial matrix: 540-578
Helical: 579-598
Mitochondrial intermembrane: 599-678

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Human SLC25A12 ELISA Kit (CAT#: V2LY-0626-LY5541)

Rabbit Anti-SLC25A12 Recombinant Antibody (CBXS-1418) (CAT#: CBMAB-S4276-CQ)

Rabbit Anti-SLC25A12 Recombinant Antibody (
10B12) (CAT#: V2LY-0725-LY1462)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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