Sign in or Register   Sign in or Register
  |  

Mouse Anti-SLC27A2 Recombinant Antibody (CBXF-2705) (CBMAB-F0162-CQ)

This product is a mouse antibody that recognizes SLC27A2. The antibody CBXF-2705 can be used for immunoassay techniques such as: ICFC.
See all SLC27A2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-2705
Antibody Isotype
IgG1
Application
ICFC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
solute carrier family 27 (fatty acid transporter), member 2
Introduction
The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
11001
UniProt ID
O14975
Alternative Names
Solute Carrier Family 27 Member 2; Solute Carrier Family 27 (Fatty Acid Transporter), Member 2; Fatty-Acid-Coenzyme A Ligase, Very Long-Chain 1; Very Long-Chain-Fatty-Acid-CoA Ligase; Long-Chain-Fatty-Acid--CoA Ligase; Fatty Acid Transport Protein 2; THCA-CoA Ligase; FACVL1; ACSVL1; FATP-2; FATP2;
Function
Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport across cell membranes, playing an important role in hepatic fatty acid uptake (PubMed:20530735, PubMed:22022213, PubMed:24269233, PubMed:10198260, PubMed:10749848, PubMed:11980911).
Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:20530735, PubMed:22022213, PubMed:24269233, PubMed:10198260, PubMed:10749848, PubMed:11980911).
Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:20530735).
Can also activate branched-chain fatty acids such as phytanic acid and pristanic acid (PubMed:10198260).
May contribute to the synthesis of sphingosine-1-phosphate (PubMed:24269233).
Does not activate C24 bile acids, cholate and chenodeoxycholate (PubMed:11980911).
In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol (PubMed:11980911).
However, it is not critical for THCA activation and bile synthesis in vivo (PubMed:20530735).
Isoform 1
Exhibits both long-chain fatty acids (LCFA) transport activity and acyl CoA synthetase towards very long-chain fatty acids (PubMed:21768100, PubMed:10198260).
Shows a preference for generating CoA derivatives of n-3 fatty acids, which are preferentially trafficked into phosphatidylinositol (PubMed:21768100).2 Publications
Isoform 2
Exhibits long-chain fatty acids (LCFA) transport activity but lacks acyl CoA synthetase towards very long-chain fatty acids.
Biological Process
Biological Process bile acid biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process fatty acid alpha-oxidationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process fatty acid beta-oxidationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process long-chain fatty acid import into cellManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process long-chain fatty acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process methyl-branched fatty acid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process very long-chain fatty acid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
Peroxisome membrane
Cell membrane
Microsome
Topology
Lumenal: 1-4
Helical: 5-27
Cytoplasmic: 28-106
Helical: 107-127
Lumenal: 128-261
Helical: 262-282
Cytoplasmic: 283-620
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SLC27A2 Recombinant Antibody (CBXF-2705)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare