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Mouse Anti-SLC4A8 Recombinant Antibody (6E11) (CBMAB-A8247-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
6E11
Antibody Isotype
IgG3, κ
Application
WB, ELISA

Basic Information

Immunogen
SLC4A8 (NP_004849, 187 a.a. ~ 286 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
solute carrier family 4, sodium bicarbonate cotransporter, member 8
Entrez Gene ID
9498
UniProt ID
Q2Y0W8
Alternative Names
DKFZp761B2318; FLJ46462; NBC3
Function
Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3- exchange with a Na+:HCO3- stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3- from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3- into the cells. Also mediates lithium-dependent HCO3- cotransport. May be regulated by osmolarity.
Biological Process
Biological Process bicarbonate transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process chloride transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process modulation of chemical synaptic transmissionISS:ARUK-UCL
Biological Process positive regulation of synaptic vesicle exocytosisISS:ARUK-UCL
Biological Process regulation of intracellular pHManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process regulation of membrane potentialManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL
Cellular Location
Membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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