SLC4A8

The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene.

Full Name

solute carrier family 4, sodium bicarbonate cotransporter, member 8

Function

Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3- exchange with a Na+:HCO3- stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3- from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3- into the cells. Also mediates lithium-dependent HCO3- cotransport. May be regulated by osmolarity.

Biological Process

Biological Process bicarbonate transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process chloride transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process ion homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process modulation of chemical synaptic transmissionISS:ARUK-UCL
Biological Process positive regulation of synaptic vesicle exocytosisISS:ARUK-UCL
Biological Process regulation of intracellular pHManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process regulation of membrane potentialManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:ARUK-UCL
Biological Process transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process transport across blood-brain barrier1 PublicationNAS:ARUK-UCL

Cellular Location

Membrane