Mouse Anti-SLC6A2 Recombinant Antibody (CBMAB-AO968LY)

Name: Mouse Anti-SLC6A2 Recombinant Antibody
SKU: CBMAB-AO968LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Application

ELISA, WB

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within mouse norepinephrine transporter.

Specificity

Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.01% BSA, 50% glycerol

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Solute Carrier Family 6 Member 2

Introduction

This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Entrez Gene ID

Mouse	20538
Rat	83511

UniProt ID

Mouse	O55192
Rat	F1LNR9

Alternative Names

Sodium-dependent noradrenaline transporter; Norepinephrine transporter; NET
Solute carrier family 6 member 2

Function

Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:2008212, PubMed:8125921).
Can also mediate sodium- and chloride-dependent transport of dopamine (PubMed:8125921, PubMed:11093780).

Biological Process

Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dopamine uptake involved in synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process monoamine transportManual Assertion Based On ExperimentIDA:MGI
Biological Process neuron cellular homeostasisManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process neurotransmitter transportISS:ARUK-UCL
Biological Process norepinephrine transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process norepinephrine uptakeISS:ARUK-UCL
Biological Process response to painIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Involvement in disease

Orthostatic intolerance (OI):
Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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