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Mouse Anti-SLC6A2 Recombinant Antibody (NET-05) (CBMAB-S6453-CQ)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
NET-05
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Synthetic peptide from the N-terminal region of mouse norepinephrine transporter
Specificity
Mouse, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 6 Member 2
Introduction
This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
Entrez Gene ID
Mouse20538
Rat83511
UniProt ID
MouseO55192
RatF1LNR9
Alternative Names
NE-T; NET; Slc6a5
Function
Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:2008212, PubMed:8125921).
Can also mediate sodium- and chloride-dependent transport of dopamine (PubMed:8125921, PubMed:11093780).
Biological Process
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dopamine uptake involved in synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process monoamine transportManual Assertion Based On ExperimentIDA:MGI
Biological Process neuron cellular homeostasisManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process neurotransmitter transportISS:ARUK-UCL
Biological Process norepinephrine transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process norepinephrine uptakeISS:ARUK-UCL
Biological Process response to painIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Involvement in disease
Orthostatic intolerance (OI):
Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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