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Mouse Anti-SLC6A2 Recombinant Antibody (CBWJN-0587) (CBMAB-N4285-WJ)

This product is a Mouse antibody that recognizes SLC6A2. The antibody CBWJN-0587 can be used for immunoassay techniques such as: IHC.
See all SLC6A2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBWJN-0587
Antibody Isotype
IgG1
Application
IHC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 40% glycerol, pH 7.2
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Solute Carrier Family 6 Member 2
Introduction
This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Entrez Gene ID
Human6530
Mouse20538
Rat83511
UniProt ID
HumanP23975
MouseO55192
RatF1LNR9
Alternative Names
Solute Carrier Family 6 Member 2; Norepinephrine Transporter; Solute Carrier Family 6 (Neurotransmitter Transporter, Noradrenalin), Member 2; Solute Carrier Family 6 (Neurotransmitter Transporter), Member 2; SLC6A5; NAT1;
Function
Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:2008212, PubMed:8125921).
Can also mediate sodium- and chloride-dependent transport of dopamine (PubMed:8125921, PubMed:11093780).
Biological Process
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Biological Process dopamine uptake involved in synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process monoamine transportManual Assertion Based On ExperimentIDA:MGI
Biological Process neuron cellular homeostasisManual Assertion Based On ExperimentTAS:ARUK-UCL
Biological Process neurotransmitter transportISS:ARUK-UCL
Biological Process norepinephrine transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process norepinephrine uptakeISS:ARUK-UCL
Biological Process response to painIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
Involvement in disease
Orthostatic intolerance (OI):
Syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. It is associated with postural tachycardia. Plasma norepinephrine concentration is abnormally high.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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