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Rabbit Anti-SLITRK1 Recombinant Antibody (CBXS-1160) (CBMAB-S4042-CQ)

This product is a rabbit antibody that recognizes SLITRK1. The antibody CBXS-1160 can be used for immunoassay techniques such as: ELISA.
See all SLITRK1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-1160
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human SLITRK1 protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SLIT And NTRK Like Family Member 1
Introduction
This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
114798
UniProt ID
Q96PX8
Alternative Names
SLIT And NTRK Like Family Member 1; Leucine-Rich Repeat-Containing Protein 12; LRRC12; SLIT And NTRK-Like Family, Member 1; Leucine Rich Repeat Containing 12; SLIT And NTRK-Like Protein 1; Slit And Trk Like Gene 1; KIAA1910; TTM;
Function
It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321).
Enhances neuronal dendrite outgrowth (PubMed:16224024, PubMed:19640509).
Biological Process
Biological Process adult behaviorIEA:Ensembl
Biological Process axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process homeostatic processIEA:Ensembl
Biological Process multicellular organism growthIEA:Ensembl
Biological Process positive regulation of axonogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of synapse assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of presynapse assemblyManual Assertion Based On ExperimentIDA:SynGO
Biological Process synapse assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process synaptic membrane adhesionManual Assertion Based On ExperimentIDA:SynGO
Cellular Location
Membrane
Secreted
Synapse
Involvement in disease
Trichotillomania (TTM):
A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder.
Topology
Extracellular: 18-622
Helical: 623-643
Cytoplasmic: 644-696
PTM
Undergoes proteolytic cleavage that results in shedding of the ectodomain and cleavage of the C-terminal cytoplasmic tail. Glycosylated. Phosphorylation at Ser-695 is necessary for proper function in promoting neurite outgrowth.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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