SLITRK1

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants.

Full Name

SLIT And NTRK Like Family Member 1

Function

It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321).
Enhances neuronal dendrite outgrowth (PubMed:16224024, PubMed:19640509).

Biological Process

Biological Process adult behaviorIEA:Ensembl
Biological Process axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process homeostatic processIEA:Ensembl
Biological Process multicellular organism growthIEA:Ensembl
Biological Process positive regulation of axonogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of synapse assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of presynapse assemblyManual Assertion Based On ExperimentIDA:SynGO
Biological Process synapse assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process synaptic membrane adhesionManual Assertion Based On ExperimentIDA:SynGO

Cellular Location

Membrane
Secreted
Synapse

Involvement in disease

Trichotillomania (TTM):
A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder.

Topology

Extracellular: 18-622
Helical: 623-643
Cytoplasmic: 644-696

PTM

Undergoes proteolytic cleavage that results in shedding of the ectodomain and cleavage of the C-terminal cytoplasmic tail. Glycosylated. Phosphorylation at Ser-695 is necessary for proper function in promoting neurite outgrowth.