Mouse Anti-SLITRK1 Recombinant Antibody (CBXS-1775) (CBMAB-S4592-CQ)

Name: Mouse Anti-SLITRK1 Recombinant Antibody (CBXS-1775)
SKU: CBMAB-S4592-CQ
Rating: 5 (1 reviews)

See all SLITRK1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBXS-1775

Application

IHC

Immunogen

NS0-derived recombinant human SLITRK1, Ala16-Ser616, Accession # Q96PX8

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Concentration

LYOPH

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SLIT And NTRK Like Family Member 1

Introduction

This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

114798

UniProt ID

Q96PX8

Alternative Names

SLIT And NTRK Like Family Member 1; Leucine-Rich Repeat-Containing Protein 12; LRRC12; SLIT And NTRK-Like Family, Member 1; Leucine Rich Repeat Containing 12; SLIT And NTRK-Like Protein 1; Slit And Trk Like Gene 1; KIAA1910; TTM;

Function

It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321).
Enhances neuronal dendrite outgrowth (PubMed:16224024, PubMed:19640509).

Biological Process

Biological Process adult behaviorIEA:Ensembl
Biological Process axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process homeostatic processIEA:Ensembl
Biological Process multicellular organism growthIEA:Ensembl
Biological Process positive regulation of axonogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of synapse assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of presynapse assemblyManual Assertion Based On ExperimentIDA:SynGO
Biological Process synapse assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process synaptic membrane adhesionManual Assertion Based On ExperimentIDA:SynGO

Cellular Location

Membrane
Secreted
Synapse

Involvement in disease

Trichotillomania (TTM):
A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder.

Topology

Extracellular: 18-622
Helical: 623-643
Cytoplasmic: 644-696

PTM

Undergoes proteolytic cleavage that results in shedding of the ectodomain and cleavage of the C-terminal cytoplasmic tail. Glycosylated. Phosphorylation at Ser-695 is necessary for proper function in promoting neurite outgrowth.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-SLITRK1 Recombinant Antibody (CBXS-1775)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-SLITRK1 Recombinant Antibody (CBXS-1160) (CAT#: CBMAB-S4042-CQ)

Mouse Anti-SLITRK1 Recombinant Antibody (CBXS-1774) (CAT#: CBMAB-S4591-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry