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Mouse Anti-SLU7 Recombinant Antibody (CBXS-5856) (CBMAB-S0710-CQ)

This product is a mouse antibody that recognizes SLU7. The antibody CBXS-5856 can be used for immunoassay techniques such as: WB.
See all SLU7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5856
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant protein encompassing a sequence within the center region of human SLU7
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SLU7 splicing factor homolog (S. cerevisiae)
Introduction
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions.
Entrez Gene ID
10569
UniProt ID
O95391
Alternative Names
SLU7 Homolog, Splicing Factor; Zinc Knuckle Motif Containing; HSlu7; SLU7 Splicing Factor Homolog (S. Cerevisiae); Pre-MRNA-Splicing Factor SLU7; SLU7 Splicing Factor Homolog; Step II Splicing Factor SLU7; Splicing Factor; 9G8;
Function
Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154).
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
Biological Process
Biological Process alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process cellular response to heatManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA 3'-splice site recognitionManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process mRNA splicing, via spliceosome1 PublicationIC:UniProtKB
Biological Process RNA splicingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentIDA:HGNC-UCL
Cellular Location
Nucleus
Nucleus speckle
Cytoplasm
Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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