SLU7

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq]

SLU7 splicing factor homolog (S. cerevisiae)

Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154).
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.

Biological Process alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process cellular response to heatManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA 3'-splice site recognitionManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process mRNA splicing, via spliceosome1 PublicationIC:UniProtKB
Biological Process RNA splicingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentIDA:HGNC-UCL

Nucleus
Nucleus speckle
Cytoplasm
Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.