SLU7

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. [provided by RefSeq]
Full Name
SLU7 splicing factor homolog (S. cerevisiae)
Function
Required for pre-mRNA splicing as component of the spliceosome (PubMed:10197984, PubMed:28502770, PubMed:30705154).
Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.
Biological Process
Biological Process alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process cellular response to heatManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process intracellular protein transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA 3'-splice site recognitionManual Assertion Based On ExperimentIDA:HGNC-UCL
Biological Process mRNA splicing, via spliceosome1 PublicationIC:UniProtKB
Biological Process RNA splicingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process RNA splicing, via transesterification reactionsManual Assertion Based On ExperimentIDA:HGNC-UCL
Cellular Location
Nucleus
Nucleus speckle
Cytoplasm
Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules.
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Anti-SLU7 antibodies

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Mouse Anti-SLU7 Recombinant Antibody (1D3-4A10) (CBMAB-A8271-LY)

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Target: SLU7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D3-4A10
Application*: WB, E
Datasheet SDS

Mouse Anti-SLU7 Recombinant Antibody (CBXS-6181) (CBMAB-S6469-CQ)

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Target: SLU7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-6181
Application*: WB
Datasheet SDS

Mouse Anti-SLU7 Recombinant Antibody (CBXS-6180) (CBMAB-S6467-CQ)

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Target: SLU7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-6180
Application*: WB
Datasheet SDS

Mouse Anti-SLU7 Recombinant Antibody (CBXS-2739) (CBMAB-S5490-CQ)

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Target: SLU7
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-2739
Application*: E, WB
Datasheet SDS

Mouse Anti-SLU7 Recombinant Antibody (CBXS-2244) (CBMAB-S5006-CQ)

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Target: SLU7
Host: Mouse
Specificity: Human
Clone: CBXS-2244
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SLU7 Recombinant Antibody (CBXS-2238) (CBMAB-S5000-CQ)

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Target: SLU7
Host: Mouse
Specificity: Human
Clone: CBXS-2238
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SLU7 Recombinant Antibody (CBXS-2142) (CBMAB-S4906-CQ)

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Target: SLU7
Host: Mouse
Specificity: Human
Clone: CBXS-2142
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-SLU7 Recombinant Antibody (CBXS-2047) (CBMAB-S4814-CQ)

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Target: SLU7
Host: Mouse
Specificity: Mouse, Rat, Human
Clone: CBXS-2047
Application*: WB, IP, IF, P, E
Datasheet SDS

Rabbit Anti-SLU7 Recombinant Antibody (CBXS-1273) (CBMAB-S4132-CQ)

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Target: SLU7
Host: Rabbit
Antibody Isotype: IgG
Specificity: Rat, Human
Clone: CBXS-1273
Application*: WB, IF
Datasheet SDS

Mouse Anti-SLU7 Recombinant Antibody (CBXS-4296) (CBMAB-S1542-CQ)

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Target: SLU7
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXS-4296
Application*: WB
Datasheet SDS

Mouse Anti-SLU7 Recombinant Antibody (CBXS-5856) (CBMAB-S0710-CQ)

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Target: SLU7
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-5856
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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