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Rabbit Anti-SMC3 Recombinant Antibody (CBXS-5394) (CBMAB-S2606-CQ)

This product is a rabbit antibody that recognizes SMC3. The antibody CBXS-5394 can be used for immunoassay techniques such as: WB, IP, IF.
See all SMC3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Chicken, Frog, Zebrafish, Cattle
Clone
CBXS-5394
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Human, Mouse, Rat, Monkey, Chicken, Frog, Zebrafish, Cattle
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
structural maintenance of chromosomes 3
Introduction
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.
Entrez Gene ID
Human9126
Mouse13006
Rat29486
Monkey695123
Chicken395188
Frog100145671
Zebrafish324475
Cattle281729
UniProt ID
HumanQ9UQE7
MouseQ9CW03
RatP97690
MonkeyF7HNK4
ChickenQ8AWB8
FrogO93309
ZebrafishQ1LVV8
CattleO97594
Alternative Names
Structural Maintenance Of Chromosomes 3; Basement Membrane-Associated Chondroitin Proteoglycan; Chondroitin Sulfate Proteoglycan 6 (Bamacan); Chromosome-Associated Polypeptide; SMC Protein 3; SMC3L1; CSPG6; HCAP; BAM;
Function
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.
Biological Process
Cell division
DNA repair
Meiotic cell cycle
Mitotic cell cycle
Mitotic spindle assembly
Regulation of DNA replication
Sister chromatid cohesion
Stem cell population maintenance
Cellular Location
Nucleus; Chromosome; Centromere. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions (By similarity).
Involvement in disease
A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. Characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies. Cornelia de Lange syndrome type 3 is a mild form with absence of major structural anomalies. The phenotype in some instances approaches that of apparently non-syndromic mental retardation.
PTM
Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation.
Phosphorylated at Ser-1083 in a SPO11-dependent manner.
Acetylation at Lys-105 and Lys-106 by ESCO1 is important for genome stability and S phase sister chromatid cohesion. Regulated by DSCC1, it is required for processive DNA synthesis, coupling sister chromatid cohesion establishment during S phase to DNA replication. Deacetylation by HDAC8, regulates release of the cohesin complex from chromatin.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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