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Mouse Anti-SMOC1 (AA 150-222) Recombinant Antibody (CBXS-0569) (CBMAB-S3511-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0569
Antibody Isotype
IgG2a
Application
ELISA, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 150-222

Target

Full Name
SPARC Related Modular Calcium Binding 1
Introduction
This gene encodes a multi-domain secreted protein that may have a critical role in ocular and limb development. Mutations in this gene are associated with microphthalmia and limb anomalies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
64093
UniProt ID
Q9H4F8
Alternative Names
SPARC Related Modular Calcium Binding 1; Secreted Modular Calcium-Binding Protein 1; SPARC-Related Modular Calcium-Binding Protein 1; SMOC-1; OAS;
Function
Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process extracellular matrix organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process eye developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process limb developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of osteoblast differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
In or around the basement membrane.
Involvement in disease
Ophthalmoacromelic syndrome (OAS):
A rare disorder presenting with ocular anomalies, ranging from mild microphthalmia to true anophthalmia, and limb anomalies. Limb malformations include fused 4th and 5th metacarpals and short 5th finger in hands, and oligodactyly in foot (four toes). Most patients have bilateral anophthalmia/ microphthalmia, but unilateral abnormality is also noted. Other malformations are rare, but venous or vertebral anomaly was recognized each in single cases.
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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