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SMOC1

This gene encodes a multi-domain secreted protein that may have a critical role in ocular and limb development. Mutations in this gene are associated with microphthalmia and limb anomalies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Full Name

SPARC Related Modular Calcium Binding 1

Function

Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.

Biological Process

Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process extracellular matrix organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process eye developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process limb developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of osteoblast differentiationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Secreted, extracellular space, extracellular matrix, basement membrane
In or around the basement membrane.

Involvement in disease

Ophthalmoacromelic syndrome (OAS):
A rare disorder presenting with ocular anomalies, ranging from mild microphthalmia to true anophthalmia, and limb anomalies. Limb malformations include fused 4th and 5th metacarpals and short 5th finger in hands, and oligodactyly in foot (four toes). Most patients have bilateral anophthalmia/ microphthalmia, but unilateral abnormality is also noted. Other malformations are rare, but venous or vertebral anomaly was recognized each in single cases.

PTM

Glycosylated.

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Anti-SMOC1 antibodies

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Mouse Anti-SMOC1 Recombinant Antibody (8F10) (CBMAB-A8385-LY)

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Target: SMOC1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 8F10

Application*: WB, E

Human Recombinant SMOC1 protein, His Tag (V2LY-0526-LY6889)

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Target: SMOC1

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-435

Tag: His Tag

Mouse Anti-SMOC1 Recombinant Antibody (CBXS-3456) (CBMAB-S6187-CQ)

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Target: SMOC1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-3456

Application*: E, IF, WB

Mouse Anti-SMOC1 (AA 150-222) Recombinant Antibody (CBXS-0570) (CBMAB-S3512-CQ)

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Target: SMOC1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-0570

Application*: E, IF, WB

Mouse Anti-SMOC1 (AA 150-222) Recombinant Antibody (CBXS-0569) (CBMAB-S3511-CQ)

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Target: SMOC1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXS-0569

Application*: E, IC, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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