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Mouse Anti-SMOC1 Recombinant Antibody (8F10) (CBMAB-A8385-LY)

The product is antibody recognizes SMOC1. The antibody 8F10 immunoassay techniques such as: WB, ELISA.
See all SMOC1 antibodies
Published Data
Fig.1 Growth and Ocular Phenotypes of Smoc1 Null Mice.
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Fig.2 smoc1 Morpholino-Treated Embryos (A and C) smoc1 morpholino-injected embryos at 2 and 5 dpf, respectively.
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Fig.3 Validation of selected proteins in low and high osteogenic BMSCs.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
8F10
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SMOC1 (NP_071420, 150 a.a. ~ 221 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SPARC Related Modular Calcium Binding 1
Entrez Gene ID
64093
UniProt ID
Q9H4F8
Function
Plays essential roles in both eye and limb development. Probable regulator of osteoblast differentiation.
Biological Process
Biological Process cell differentiationIEA:UniProtKB-KW
Biological Process extracellular matrix organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process eye developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process limb developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of osteoblast differentiationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
In or around the basement membrane.
Involvement in disease
Ophthalmoacromelic syndrome (OAS):
A rare disorder presenting with ocular anomalies, ranging from mild microphthalmia to true anophthalmia, and limb anomalies. Limb malformations include fused 4th and 5th metacarpals and short 5th finger in hands, and oligodactyly in foot (four toes). Most patients have bilateral anophthalmia/ microphthalmia, but unilateral abnormality is also noted. Other malformations are rare, but venous or vertebral anomaly was recognized each in single cases.
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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