Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-SMPDL3B (AA 274-373) Recombinant Antibody (CBXS-0574) (CBMAB-S3516-CQ)


See all SMPDL3B antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0574
Antibody Isotype
IgG3, κ
Application
ELISA, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 274-373

Target

Full Name
Sphingomyelin Phosphodiesterase Acid Like 3B
Introduction
SMPDL3B (Sphingomyelin Phosphodiesterase Acid Like 3B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity and sphingomyelin phosphodiesterase activity. An important paralog of this gene is SMPDL3A.
Entrez Gene ID
27293
UniProt ID
Q92485
Alternative Names
Sphingomyelin Phosphodiesterase Acid Like 3B; ASM-Like Phosphodiesterase 3b; ASML3B; Acid Sphingomyelinase-Like Phosphodiesterase 3b; Sphingomyelin Phosphodiesterase, Acid-Like 3B; Sphingomyelin Phosphodiesterase Acid-Like 3B; EC 3.1.4.-; ASMLPD;
Function
Lipid-modulating phosphodiesterase (PubMed:26095358).
Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity).
Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358).
Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity).
Biological Process
Biological Process inflammatory responseIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process membrane lipid catabolic processISS:UniProtKB
Biological Process negative regulation of inflammatory responseISS:UniProtKB
Biological Process negative regulation of toll-like receptor signaling pathwayISS:UniProtKB
Biological Process sphingomyelin catabolic processIEA:InterPro
Cellular Location
Secreted
Cell membrane
PTM
N-glycosylated.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SMPDL3B (AA 274-373) Recombinant Antibody (CBXS-0574)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry