Mouse Anti-SMPDL3B (AA 274-373) Recombinant Antibody (CBXS-0574) (CBMAB-S3516-CQ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity).
Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358).
Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity).
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process membrane lipid catabolic processISS:UniProtKB
Biological Process negative regulation of inflammatory responseISS:UniProtKB
Biological Process negative regulation of toll-like receptor signaling pathwayISS:UniProtKB
Biological Process sphingomyelin catabolic processIEA:InterPro
Cell membrane
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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