SMPDL3B

SMPDL3B (Sphingomyelin Phosphodiesterase Acid Like 3B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include hydrolase activity and sphingomyelin phosphodiesterase activity. An important paralog of this gene is SMPDL3A.

Full Name

Sphingomyelin Phosphodiesterase Acid Like 3B

Function

Lipid-modulating phosphodiesterase (PubMed:26095358).
Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity).
Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358).
Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity).

Biological Process

Biological Process inflammatory responseIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process membrane lipid catabolic processISS:UniProtKB
Biological Process negative regulation of inflammatory responseISS:UniProtKB
Biological Process negative regulation of toll-like receptor signaling pathwayISS:UniProtKB
Biological Process sphingomyelin catabolic processIEA:InterPro

Cellular Location

Secreted
Cell membrane

PTM

N-glycosylated.