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Mouse Anti-SMPDL3B Recombinant Antibody (5E12) (CBMAB-A8388-LY)

The product is antibody recognizes SMPDL3B. The antibody 5E12 immunoassay techniques such as: WB, ELISA.
See all SMPDL3B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5E12
Antibody Isotype
IgG3, κ
Application
WB, ELISA

Basic Information

Immunogen
SMPDL3B (NP_001009568, 274 a.a. ~ 372 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Sphingomyelin Phosphodiesterase Acid Like 3B
Entrez Gene ID
27293
UniProt ID
Q92485
Alternative Names
ASML3B
Function
Lipid-modulating phosphodiesterase (PubMed:26095358).
Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity).
Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358).
Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity).
Biological Process
Biological Process inflammatory responseIEA:UniProtKB-KW
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process membrane lipid catabolic processISS:UniProtKB
Biological Process negative regulation of inflammatory responseISS:UniProtKB
Biological Process negative regulation of toll-like receptor signaling pathwayISS:UniProtKB
Biological Process sphingomyelin catabolic processIEA:InterPro
Cellular Location
Secreted
Cell membrane
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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