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Mouse Anti-SND1 Recombinant Antibody (CBYJT-1677) (CBMAB-T0727-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to SND1 (Staphylococcal Nuclease And Tudor Domain Containing 1). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all SND1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
CBYJT-1677
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Specific for an epitope mapping between amino acids 894-910 at the C-terminus of TudorSN of human origin
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 894-910

Target

Full Name
Staphylococcal Nuclease And Tudor Domain Containing 1
Introduction
SND1 is a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. SND1 is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC).
Entrez Gene ID
Human27044
Mouse56463
Rat64635
UniProt ID
HumanQ7KZF4
MouseQ78PY7
RatQ66X93
Alternative Names
Staphylococcal Nuclease And Tudor Domain Containing 1; Tudor Domain-Containing Protein 11; EBNA2 Coactivator P100; Tudor-SN; TDRD11; Staphylococcal Nuclease Domain-Containing Protein 1
Function
Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:28546213, PubMed:18453631).
As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213).
Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934).
Plays a role in PIM1 regulation of MYB activity (PubMed:9809063).
Functions as a transcriptional coactivator for STAT5 (By similarity).
(Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).
Biological Process
Biological Process gene silencing by RNAIEA:InterPro
Biological Process miRNA catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process osteoblast differentiationManual Assertion Based On ExperimentHDA:UniProtKB
Biological Process regulation of cell cycle processManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Nucleus
Melanosome
In IL-4 stimulated cells colocalizes with STAT6 in the nucleus (PubMed:12234934).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).
PTM
Phosphorylated by PIM1 in vitro.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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