Mouse Anti-SND1 Recombinant Antibody (CBYJT-1677) (CBMAB-T0727-YJ)

Name: Mouse Anti-SND1 Recombinant Antibody (CBYJT-1677)
SKU: CBMAB-T0727-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-1677

Application

WB, IP, IF, ELISA

Immunogen

Specific for an epitope mapping between amino acids 894-910 at the C-terminus of TudorSN of human origin

Specificity

Human, Rat, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 894-910

More Infomation

Target

Full Name

Staphylococcal Nuclease And Tudor Domain Containing 1

Introduction

SND1 is a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. SND1 is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC).

Entrez Gene ID

Human	27044
Mouse	56463
Rat	64635

UniProt ID

Human	Q7KZF4
Mouse	Q78PY7
Rat	Q66X93

Alternative Names

Staphylococcal Nuclease And Tudor Domain Containing 1; Tudor Domain-Containing Protein 11; EBNA2 Coactivator P100; Tudor-SN; TDRD11; Staphylococcal Nuclease Domain-Containing Protein 1

Function

Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:28546213, PubMed:18453631).
As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213).
Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934).
Plays a role in PIM1 regulation of MYB activity (PubMed:9809063).
Functions as a transcriptional coactivator for STAT5 (By similarity).
(Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).

Biological Process

Biological Process gene silencing by RNAIEA:InterPro
Biological Process miRNA catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process osteoblast differentiationManual Assertion Based On ExperimentHDA:UniProtKB
Biological Process regulation of cell cycle processManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Nucleus
Melanosome
In IL-4 stimulated cells colocalizes with STAT6 in the nucleus (PubMed:12234934).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).

PTM

Phosphorylated by PIM1 in vitro.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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