SND1

This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]

Staphylococcal Nuclease And Tudor Domain Containing 1

Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:28546213, PubMed:18453631).
As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213).
Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934).
Plays a role in PIM1 regulation of MYB activity (PubMed:9809063).
Functions as a transcriptional coactivator for STAT5 (By similarity).
(Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).

Biological Process gene silencing by RNAIEA:InterPro
Biological Process miRNA catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mRNA catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process osteoblast differentiationManual Assertion Based On ExperimentHDA:UniProtKB
Biological Process regulation of cell cycle processManual Assertion Based On ExperimentIMP:UniProtKB

Cytoplasm
Nucleus
Melanosome
In IL-4 stimulated cells colocalizes with STAT6 in the nucleus (PubMed:12234934).
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065).

Phosphorylated by PIM1 in vitro.