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Mouse Anti-SNRNP70 Recombinant Antibody (CBFYS-001) (CBMAB-S0001-FY)

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Datasheet
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Basic Information

Host Animal
Mouse
Clone
CBFYS-001
Application
ICC, IP, WB
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Small Nuclear Ribonucleoprotein U1 Subunit 70
Introduction
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
Entrez Gene ID
Human6625
Mouse20637
Rat361574
UniProt ID
HumanP08621
MouseQ62376
RatB2RZ74
Alternative Names
RPU1; Snp1; U1AP; U170K; U1RNP; RNPU1Z; SNRP70; U1-70K
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158).
SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158).
Isoform 3
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
Isoform 4
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
Biological Process
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of chaperone-mediated autophagyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process negative regulation of protein refoldingManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process positive regulation of mRNA splicing, via spliceosomeIEA:Ensembl
Biological Process regulation of ATP-dependent activityManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process regulation of RNA splicingManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Nucleus speckle
Nucleus, nucleoplasm
Colocalizes with SCNM1 and LUC7L2 in nuclear speckles.
PTM
The N-terminus is blocked.
Extensively phosphorylated on serine residues in the C-terminal region.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SNRNP70 Recombinant Antibody (CBXS-5734) (CAT#: CBMAB-S0597-CQ)

Isotype control

For research use only. Not intended for any clinical use.

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