SNRNP70

SNRNP70 (Small Nuclear Ribonucleoprotein U1 Subunit 70) is a Protein Coding gene. Diseases associated with SNRNP70 include Mixed Connective Tissue Disease and Systemic Lupus Erythematosus. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is SNRNP35.

Full Name

Small Nuclear Ribonucleoprotein U1 Subunit 70

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158).
SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158).
Isoform 3
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
Isoform 4
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.

Biological Process

Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of chaperone-mediated autophagyManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process negative regulation of protein refoldingManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process positive regulation of mRNA splicing, via spliceosomeIEA:Ensembl
Biological Process regulation of ATP-dependent activityManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process regulation of RNA splicingManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus speckle
Nucleus, nucleoplasm
Colocalizes with SCNM1 and LUC7L2 in nuclear speckles.

PTM

The N-terminus is blocked.
Extensively phosphorylated on serine residues in the C-terminal region.