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Mouse Anti-SNTB2 Recombinant Antibody (CBXS-5608) (CBMAB-S0486-CQ)

This product is a mouse antibody that recognizes SNTB2. The antibody CBXS-5608 can be used for immunoassay techniques such as: ELISA.
See all SNTB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5608
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
Partial recombinant corresponding to aa116-211 from human SNTB2 (NP_006741) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
Introduction
Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein encoded by this gene is a peripheral membrane protein found associated with dystrophin and dystrophin-related proteins. This gene is a member of the syntrophin gene family, which contains at least two other structurally-related genes.
Entrez Gene ID
6645
UniProt ID
Q13425
Alternative Names
Syntrophin Beta 2; Syntrophin, Beta 2 (Dystrophin-Associated Protein A1, 59kDa, Basic Component 2); 59 KDa Dystrophin-Associated Protein A1 Basic Component 2; Syntrophin-3; D16S2531E; SNT2B2; SNTL;
Function
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May play a role in the regulation of secretory granules via its interaction with PTPRN.
Cellular Location
Membrane
Cytoplasmic vesicle, secretory vesicle membrane
Cell junction
Cytoplasm, cytoskeleton
Membrane-associated. In muscle, it is exclusively localized at the neuromuscular junction (By similarity).
In insulinoma cell line, it is enriched in secretory granules
PTM
Phosphorylated. Partially dephosphorylated upon insulin stimulation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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