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Mouse Anti-SNU13 Recombinant Antibody (5C5) (CBMAB-A5973-LY)

The product is antibody recognizes NHP2L1. The antibody 5C5 immunoassay techniques such as: sELISA, ELISA.
See all SNU13 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5C5
Antibody Isotype
IgG1, κ
Application
sELISA, ELISA

Basic Information

Immunogen
NHP2L1 (AAH05358, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)
Introduction
Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Entrez Gene ID
4809
UniProt ID
P55769
Alternative Names
15.5K; FA-1; FA1; NHPX; OTK27; SNRNP15-5; SNU13; SPAG12; SSFA1
Function
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166).
Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961).
The protein undergoes a conformational change upon RNA-binding (PubMed:17412961).
Biological Process
Biological Process box C/D snoRNP assemblyIEA:Ensembl
Biological Process maturation of LSU-rRNAManual Assertion Based On ExperimentIBA:GO_Central
Biological Process maturation of SSU-rRNAManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process single fertilizationIEA:Ensembl
Cellular Location
Nucleus
Nucleus, nucleolus
Concentrated in the dense fibrillar component of the nucleolus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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