SNU13

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene.

Full Name

SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5)

Function

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166).
Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961).
The protein undergoes a conformational change upon RNA-binding (PubMed:17412961).

Biological Process

Biological Process box C/D snoRNP assemblyIEA:Ensembl
Biological Process maturation of LSU-rRNAManual Assertion Based On ExperimentIBA:GO_Central
Biological Process maturation of SSU-rRNAManual Assertion Based On ExperimentIBA:GO_Central
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process single fertilizationIEA:Ensembl

Cellular Location

Nucleus
Nucleus, nucleolus
Concentrated in the dense fibrillar component of the nucleolus.

Anti-SNU13 antibodies

Mouse Anti-SNU13 Recombinant Antibody (5C5) (CBMAB-N2440-WJ)

Datasheet

SDS

Target: SNU13

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5C5

Application*: E

Rabbit Anti-SNU13 Recombinant Antibody (CBWJN-1404) (CBMAB-N2441-WJ)

Datasheet

SDS

Target: SNU13

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBWJN-1404

Application*: WB, IP, P, F, IC

Mouse Anti-SNU13 Recombinant Antibody (5C5) (CBMAB-A5973-LY)

Datasheet

SDS

Target: SNU13

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5C5

Application*: SE, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)