Mouse Anti-SNX33 Recombinant Antibody (3A1) (CBMAB-A8103-LY)

Name: Mouse Anti-SNX33 Recombinant Antibody (3A1)
SKU: CBMAB-A8103-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3A1

Application

WB, ELISA

Immunogen

SH3PX3 (NP_695003, 475 a.a. ~ 574 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Sorting Nexin 33

Entrez Gene ID

257364

UniProt ID

Q8WV41

Alternative Names

MGC32065; SH3PX3; SH3PXD3C; SNX30

Function

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

Biological Process

Biological Process cleavage furrow formationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosomal transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosome organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportIEA:InterPro
Biological Process macropinocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein importManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm, cytosol
Membrane
Cytoplasmic vesicle membrane
Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773).
Not associated with membranes (PubMed:21048941).

PTM

Phosphorylated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Mouse Anti-SNX33 Recombinant Antibody (CBXS-2993) (CAT#: CBMAB-S5739-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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