SNX33

The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene.

Full Name

Sorting Nexin 33

Function

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

Biological Process

Biological Process cleavage furrow formationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosomal transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosome organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportIEA:InterPro
Biological Process macropinocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein importManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasm, cytosol
Membrane
Cytoplasmic vesicle membrane
Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773).
Not associated with membranes (PubMed:21048941).

PTM

Phosphorylated.