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Mouse Anti-SNX33 Recombinant Antibody (CBXS-2993) (CBMAB-S5739-CQ)

This product is a mouse antibody that recognizes SNX33. The antibody CBXS-2993 can be used for immunoassay techniques such as: ELISA, WB.
See all SNX33 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-2993
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa475-575 from human SH3PX3 (NP_695003) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sorting Nexin 33
Introduction
The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
257364
UniProt ID
Q8WV41
Alternative Names
Sorting Nexin 33; SH3 And PX Domain-Containing Protein 3; SH3 And PX Domain Containing 3; SH3PXD3C; SH3PX3; SNX30; Sorting Nexin-33;
Function
Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.
Biological Process
Biological Process cleavage furrow formationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosomal transportManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process endosome organizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process intracellular protein transportIEA:InterPro
Biological Process macropinocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitotic cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process negative regulation of endocytosisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of protein localization to cell surfaceManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein importManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytosol
Membrane
Cytoplasmic vesicle membrane
Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773).
Not associated with membranes (PubMed:21048941).
PTM
Phosphorylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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