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Mouse Anti-SNX4 Recombinant Antibody (4H8) (CBMAB-A8441-LY)

The product is antibody recognizes SNX4. The antibody 4H8 immunoassay techniques such as: WB, ELISA.
See all SNX4 antibodies
Published Data
Fig.1 SNX4 was determined by western blotting with a specific SNX4 antibody.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
4H8
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SNX4 (AAH18762, 341 a.a. ~ 450 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Sorting Nexin 4
Introduction
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. [provided by RefSeq]
Entrez Gene ID
8723
UniProt ID
O95219
Function
Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622).
Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011).
Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622).
Biological Process
Biological Process endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of histamine secretion by mast cellManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Early endosome membrane
Also detected on a juxtanuclear endocytic recycling compartment (ERC).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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