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SNX4

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]

Full Name

Sorting Nexin 4

Function

Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622).
Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011).
Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622).

Biological Process

Biological Process endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of histamine secretion by mast cellManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transportManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Early endosome membrane
Also detected on a juxtanuclear endocytic recycling compartment (ERC).

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Anti-SNX4 antibodies

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Mouse Anti-SNX4 Recombinant Antibody (4H8) (CBMAB-A8441-LY)

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Target: SNX4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4H8

Application*: WB, E

Mouse Anti-SNX4 Recombinant Antibody (CBXS-3264) (CBMAB-S6005-CQ)

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Target: SNX4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBXS-3264

Application*: E, WB

Rabbit Anti-SNX4 Recombinant Antibody (CBXS-1429) (CBMAB-S4287-CQ)

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Target: SNX4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBXS-1429

Application*: WB, IP, IF

Human SNX4 ELISA Kit (V2LY-0626-LY3185)

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Target: SNX4

Sensitivity: 0.0099 ng/mL

Detection Range: 0.02-4.5 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

SNX4 Matched Antibody Pair (1120) (APMAB-1120LY)

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Target: SNX4

Specificity: Human

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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