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Rabbit Anti-SNX4 Recombinant Antibody (CBXS-1429) (CBMAB-S4287-CQ)

This product is a rabbit antibody that recognizes SNX4. The antibody CBXS-1429 can be used for immunoassay techniques such as: WB, IP, IF.
See all SNX4 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1429
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sorting Nexin 4
Introduction
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene.
Entrez Gene ID
Human8723
Mouse69150
Rat360725
UniProt ID
HumanO95219
MouseQ91YJ2
RatB2RYI6
Alternative Names
Sorting Nexin 4; Sorting Nexin-4; ATG24B;
Function
Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622).
Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011).
Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622).
Biological Process
Biological Process endocytic recyclingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of autophagosome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of histamine secretion by mast cellManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein transportManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Early endosome membrane
Also detected on a juxtanuclear endocytic recycling compartment (ERC).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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