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Mouse Anti-SOAT1 Recombinant Antibody (CBXS-6112) (CBMAB-S2947-CQ)

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Basic Information

Host Animal
Mouse
Clone
CBXS-6112
Application
WB, ELISA, IHC-P
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Sterol O-Acyltransferase 1
Introduction
The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
6646
UniProt ID
P35610
Alternative Names
Sterol O-Acyltransferase 1; Sterol O-Acyltransferase (Acyl-Coenzyme A: Cholesterol Acyltransferase) 1; Acyl-Coenzyme A:Cholesterol Acyltransferase 1; EC 2.3.1.26; ACAT-1; ACACT; ACAT1;
Function
Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:9020103, PubMed:32433614, PubMed:32433613, PubMed:32944968).
Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103).
Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614).
Biological Process
Biological Process cholesterol effluxManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cholesterol esterificationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cholesterol homeostasisManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process cholesterol metabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process cholesterol storageManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process low-density lipoprotein particle clearanceTAS:Reactome
Biological Process macrophage derived foam cell differentiationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process positive regulation of amyloid precursor protein biosynthetic processManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process very-low-density lipoprotein particle assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-138
Helical: 139-160
Lumenal: 161-180
Helical: 181-206
Cytoplasmic: 207-218
Helical: 219-244
Lumenal: 245-252
Helical: 253-276
Cytoplasmic: 277-319
Helical: 320-352
Lumenal: 353-369
Helical: 370-395
Cytoplasmic: 396-443
Helical: 444-468
Lumenal: 469-474
Helical: 475-490
Cytoplasmic: 491-496
Helical: 497-528
Lumenal: 529-550
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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