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Mouse Anti-SOD3 Recombinant Antibody (5C3) (CBMAB-A8452-LY)

The product is antibody recognizes SOD3. The antibody 5C3 immunoassay techniques such as: WB, ELISA.
See all SOD3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5C3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SOD3 (AAH14418, 26 a.a. ~ 125 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
superoxide dismutase 3, extracellular
Introduction
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq]
Entrez Gene ID
6649
UniProt ID
P08294
Alternative Names
EC-SOD; MGC20077
Function
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Biological Process
Biological Process blood vessel diameter maintenanceIEA:Ensembl
Biological Process removal of superoxide radicalsManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to copper ionIEA:Ensembl
Biological Process response to hypoxiaIEA:Ensembl
Cellular Location
Secreted, extracellular space
Golgi apparatus, trans-Golgi network
99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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