SOD3

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq]

superoxide dismutase 3, extracellular

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.

Biological Process blood vessel diameter maintenanceIEA:Ensembl
Biological Process removal of superoxide radicalsManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to copper ionIEA:Ensembl
Biological Process response to hypoxiaIEA:Ensembl

Secreted, extracellular space
Golgi apparatus, trans-Golgi network
99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.