SOD3

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq]
Full Name
superoxide dismutase 3, extracellular
Function
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Biological Process
Biological Process blood vessel diameter maintenanceIEA:Ensembl
Biological Process removal of superoxide radicalsManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to copper ionIEA:Ensembl
Biological Process response to hypoxiaIEA:Ensembl
Cellular Location
Secreted, extracellular space
Golgi apparatus, trans-Golgi network
99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.
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Anti-SOD3 antibodies

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Mouse Anti-SOD3 Recombinant Antibody (5C3) (CBMAB-A8452-LY)

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Target: SOD3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5C3
Application*: WB, E
Datasheet SDS

Mouse Anti-SOD3 Recombinant Antibody (CBXS-2363) (CBMAB-S5121-CQ)

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Target: SOD3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-2363
Application*: E, IH, IP, WB
Datasheet SDS

Mouse Anti-SOD3 Recombinant Antibody (CBXS-2349) (CBMAB-S5108-CQ)

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Target: SOD3
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: CBXS-2349
Application*: IC, IH, WB
Datasheet SDS

Mouse Anti-SOD3 Recombinant Antibody (CBXS-1901) (CBMAB-S4691-CQ)

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Target: SOD3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXS-1901
Application*: WB
Datasheet SDS

Rabbit Anti-SOD3 Recombinant Antibody (CBXS-1262) (CBMAB-S4121-CQ)

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Target: SOD3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXS-1262
Application*: WB, P
Datasheet SDS

Mouse Anti-SOD3 Recombinant Antibody (CBXS-0649) (CBMAB-S3586-CQ)

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Target: SOD3
Host: Mouse
Specificity: Rat
Clone: CBXS-0649
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SOD3 Recombinant Antibody (CBXS-0648) (CBMAB-S3585-CQ)

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Target: SOD3
Host: Mouse
Specificity: Human
Clone: CBXS-0648
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-SOD3 Recombinant Antibody (CBXS-0647) (CBMAB-S3584-CQ)

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Target: SOD3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBXS-0647
Application*: E, IH, IP, WB
Datasheet SDS

Mouse Anti-SOD3 Recombinant Antibody (CBXS-0646) (CBMAB-S3583-CQ)

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Target: SOD3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-0646
Application*: IC, IH, WB
Datasheet SDS

Mouse Anti-SOD3 Recombinant Antibody (CBXS-5152) (CBMAB-S2370-CQ)

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Target: SOD3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXS-5152
Application*: E, WB
Datasheet SDS

Mouse Anti-SOD3 Recombinant Antibody (CBXS-4208) (CBMAB-S1461-CQ)

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Target: SOD3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXS-4208
Application*: E, F, IC, IF, P, IP, WB
Datasheet SDS

Mouse Anti-SOD3 Recombinant Antibody (CBXS-5695) (CBMAB-S0266-CQ)

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Target: SOD3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXS-5695
Application*: WB, E, IH, IF, P
Datasheet SDS

Mouse Anti-SOD3 Recombinant Antibody (4GG11G6) (CBMAB-S0018-CQ)

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Target: SOD3
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Guinea pig
Clone: 4GG11G6
Application*: WB, IH, IF, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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