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Mouse Anti-SOD3 Recombinant Antibody (CBXS-2349) (CBMAB-S5108-CQ)

This product is a mouse antibody that recognizes SOD3. The antibody CBXS-2349 can be used for immunoassay techniques such as: ICC, IHC, WB.
See all SOD3 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXS-2349
Application
ICC, IHC, WB

Basic Information

Immunogen
Human EC-SOD purified from aortas
Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.09% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
superoxide dismutase 3, extracellular
Introduction
This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk.
Entrez Gene ID
Human6649
Mouse20657
Rat25352
UniProt ID
HumanP08294
MouseO09164
RatQ08420
Alternative Names
Superoxide Dismutase 3; Superoxide Dismutase 3, Extracellular; EC 1.15.1.1; EC-SOD; Extracellular Superoxide Dismutase [Cu-Zn]; Testicular Tissue Protein Li 175;
Function
Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen.
Biological Process
Biological Process blood vessel diameter maintenanceIEA:Ensembl
Biological Process removal of superoxide radicalsManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to copper ionIEA:Ensembl
Biological Process response to hypoxiaIEA:Ensembl
Cellular Location
Secreted, extracellular space
Golgi apparatus, trans-Golgi network
99% of EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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