Mouse Anti-SPI1 Recombinant Antibody (CBXS-4115) (CBMAB-S1370-CQ)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity).
Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity).
May be particularly important for the pro- to pre-B cell transition (PubMed:33951726).
Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726).
In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity).
Defense response to tumor cell
Endothelial to hematopoietic transition
Interleukin-6-mediated signaling pathway
Myeloid leukocyte differentiation
Negative regulation of adipose tissue development
Negative regulation of DNA-templated transcription
Negative regulation of gene expression
Negative regulation of neutrophil degranulation
Negative regulation of NF-kappaB transcription factor activity
Negative regulation of non-canonical NF-kappaB signal transduction
Negative regulation of protein localization to chromatin
Negative regulation of transcription by RNA polymerase II
Oncogene-induced cell senescence
Pericyte cell differentiation
Positive regulation of antifungal innate immune response
Positive regulation of B cell differentiation
Positive regulation of microglial cell mediated cytotoxicity
Positive regulation of miRNA transcription
Positive regulation of p38MAPK cascade
Positive regulation of transcription by RNA polymerase II
Pro-T cell differentiation
Regulation of DNA-binding transcription factor activity
Regulation of DNA-templated transcription
Regulation of erythrocyte differentiation
Regulation of myeloid progenitor cell differentiation
Regulation of transcription by RNA polymerase II
TRAIL-activated apoptotic signaling pathway
Transcription initiation-coupled chromatin remodeling
A form of agammaglobulinemia, a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
Antibody Pairs
SPI1 Matched Antibody Pair (1131) (CAT#: APMAB-1131LY)
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Rabbit Anti-Spi1 Recombinant Antibody (CBYC-P843) (CAT#: CBMAB-P3695-YC)
SPI1 Matched Antibody Pair (1131) (CAT#: APMAB-1131LY)
Mouse Anti-SPI1 Recombinant Antibody (CBXS-3805) (CAT#: CBMAB-S1076-CQ)
Mouse Anti-Spi1 Recombinant Antibody (C-3) (CAT#: CBMAB-P3694-YC)
Mouse Anti-SPI1 Recombinant Antibody (CBXS-5157) (CAT#: CBMAB-S2375-CQ)
Rabbit Anti-SPI1 (Internal) Recombinant Antibody (SP238) (CAT#: CBMAB-S6595-CQ)
Mouse Anti-SPI1 Recombinant Antibody (CBT4079) (CAT#: V2LY-0625-LY2739)
Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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