SPI1

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.

Full Name

Spi-1 proto-oncogene

Research Area

Immunology

Function

Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (PubMed:23658224, PubMed:33951726).
Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R (By similarity).
Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (By similarity).
May be particularly important for the pro- to pre-B cell transition (PubMed:33951726).
Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (PubMed:33951726).
In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity).

Biological Process

Cell differentiation
Defense response to tumor cell
Endothelial to hematopoietic transition
Interleukin-6-mediated signaling pathway
Myeloid leukocyte differentiation
Negative regulation of adipose tissue development
Negative regulation of DNA-templated transcription
Negative regulation of gene expression
Negative regulation of neutrophil degranulation
Negative regulation of NF-kappaB transcription factor activity
Negative regulation of non-canonical NF-kappaB signal transduction
Negative regulation of protein localization to chromatin
Negative regulation of transcription by RNA polymerase II
Oncogene-induced cell senescence
Pericyte cell differentiation
Positive regulation of antifungal innate immune response
Positive regulation of B cell differentiation
Positive regulation of microglial cell mediated cytotoxicity
Positive regulation of miRNA transcription
Positive regulation of p38MAPK cascade
Positive regulation of transcription by RNA polymerase II
Pro-T cell differentiation
Regulation of DNA-binding transcription factor activity
Regulation of DNA-templated transcription
Regulation of erythrocyte differentiation
Regulation of myeloid progenitor cell differentiation
Regulation of transcription by RNA polymerase II
TRAIL-activated apoptotic signaling pathway
Transcription initiation-coupled chromatin remodeling

Cellular Location

Nucleus

Involvement in disease

Agammaglobulinemia 10, autosomal dominant (AGM10):
A form of agammaglobulinemia, a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

Anti-SPI1 antibodies

+ Filters

Mouse Anti-SPI1 Recombinant Antibody (CBT4079) (V2LY-0625-LY2739)

Compare

Target: SPI1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBT4079

Application*: F

SPI1

Anti-SPI1 antibodies

Hot products