Sign in or Register   Sign in or Register
  |  

Mouse Anti-SPINK1 Recombinant Antibody (1B12) (CBMAB-A8538-LY)

The product is antibody recognizes SPINK1. The antibody 1B12 immunoassay techniques such as: WB, ELISA.
See all SPINK1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B12
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
SPINK1 (AAH25790, 24 a.a. ~ 79 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Serine Peptidase Inhibitor, Kazal Type 1
Introduction
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq]
Entrez Gene ID
6690
UniProt ID
P00995
Alternative Names
PCTT; PSTI; Spink3; TATI
Function
Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:7142173).
In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity).
In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.
Biological Process
Biological Process cellular response to peptide hormone stimulusIEA:Ensembl
Biological Process negative regulation of calcium ion importIEA:Ensembl
Biological Process negative regulation of nitric oxide mediated signal transductionIEA:Ensembl
Biological Process negative regulation of peptidyl-tyrosine phosphorylationIEA:Ensembl
Biological Process negative regulation of serine-type endopeptidase activityIEA:Ensembl
Biological Process nitric oxide mediated signal transductionIEA:Ensembl
Biological Process peptidyl-tyrosine phosphorylationIEA:Ensembl
Biological Process positive regulation of cytosolic calcium ion concentrationIEA:Ensembl
Biological Process positive regulation of epithelial cell proliferationIEA:Ensembl
Biological Process positive regulation of pancreatic juice secretionIEA:Ensembl
Biological Process positive regulation of peptide hormone secretionIEA:Ensembl
Biological Process regulation of acrosome reactionIEA:Ensembl
Biological Process regulation of store-operated calcium entryIEA:Ensembl
Biological Process response to ethanolIEA:Ensembl
Biological Process response to nutrient levelsIEA:Ensembl
Biological Process sperm capacitationIEA:Ensembl
Cellular Location
Secreted
Involvement in disease
Pancreatitis, hereditary (PCTT):
A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.
Tropical calcific pancreatitis (TCP):
Idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SPINK1 Recombinant Antibody (1B12)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare