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Mouse Anti-SRGN Recombinant Antibody (CBXS-4016) (CBMAB-S1277-CQ)

This product is a mouse antibody that recognizes SRGN. The antibody CBXS-4016 can be used for immunoassay techniques such as: ELISA, WB.
See all SRGN antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4016
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
serglycin
Introduction
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. Two transcript variants, only one of them protein-coding, have been found for this gene.
Entrez Gene ID
5552
UniProt ID
P10124
Alternative Names
Serglycin; Secretory Granule Proteoglycan Core Protein; Hematopoietic Proteoglycan Core Protein; Platelet Proteoglycan Core Protein; Proteoglycan 1, Secretory Granule; Serglycin Proteoglycan; PRG1; P.PG;
Function
Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.
Biological Process
Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process biomineral tissue developmentIEA:UniProtKB-KW
Biological Process granzyme-mediated programmed cell death signaling pathwayManual Assertion Based On ExperimentIDA:GO_Central
Biological Process maintenance of granzyme B location in T cell secretory granuleISS:UniProtKB
Biological Process maintenance of protease location in mast cell secretory granuleISS:UniProtKB
Biological Process mast cell secretory granule organizationISS:UniProtKB
Biological Process negative regulation of bone mineralizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cytokine productionISS:UniProtKB
Biological Process protein processingISS:UniProtKB
Biological Process secretory granule organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process T cell secretory granule organizationISS:UniProtKB
Cellular Location
Cytoplasmic granule
Cytolytic granule
Secreted, extracellular space
Golgi apparatus
Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity).
Secreted constitutively by endothelial cells and macrophages (PubMed:11154222).
Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585).
PTM
O-glycosylated; contains chondroitin sulfate and heparan sulfate.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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