Human Recombinant SRGN protein, His Tag (V2LY-0526-LY6714)

Name: Human Recombinant SRGN protein, His Tag
SKU: V2LY-0526-LY6714
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant SRGN protein, His Tag consist of Amino Acid: 1-158 and predicts a molecular mass of 16.1 kDa.

Molecule Mass

16.1 kDa

Verified

HPLC

Sequence

Amino Acid: 1-158

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

serglycin

Function

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.

Biological Process

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process biomineral tissue developmentIEA:UniProtKB-KW
Biological Process granzyme-mediated programmed cell death signaling pathwayManual Assertion Based On ExperimentIDA:GO_Central
Biological Process maintenance of granzyme B location in T cell secretory granuleISS:UniProtKB
Biological Process maintenance of protease location in mast cell secretory granuleISS:UniProtKB
Biological Process mast cell secretory granule organizationISS:UniProtKB
Biological Process negative regulation of bone mineralizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cytokine productionISS:UniProtKB
Biological Process protein processingISS:UniProtKB
Biological Process secretory granule organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process T cell secretory granule organizationISS:UniProtKB

Cellular Location

Cytoplasmic granule
Cytolytic granule
Secreted, extracellular space
Golgi apparatus
Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity).
Secreted constitutively by endothelial cells and macrophages (PubMed:11154222).
Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585).

PTM

O-glycosylated; contains chondroitin sulfate and heparan sulfate.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant SRGN protein, His & Myc Tag (CAT#: V2LY-0526-LY6713)

Related Products

Mouse Anti-SRGN Recombinant Antibody (CBXS-4016) (CAT#: CBMAB-S1277-CQ)

Human Recombinant SRGN protein, His & Myc Tag (CAT#: V2LY-0526-LY6713)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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