SRGN

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis. [provided by RefSeq]

serglycin

Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization.

Biological Process apoptotic processIEA:UniProtKB-KW
Biological Process biomineral tissue developmentIEA:UniProtKB-KW
Biological Process granzyme-mediated programmed cell death signaling pathwayManual Assertion Based On ExperimentIDA:GO_Central
Biological Process maintenance of granzyme B location in T cell secretory granuleISS:UniProtKB
Biological Process maintenance of protease location in mast cell secretory granuleISS:UniProtKB
Biological Process mast cell secretory granule organizationISS:UniProtKB
Biological Process negative regulation of bone mineralizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cytokine productionISS:UniProtKB
Biological Process protein processingISS:UniProtKB
Biological Process secretory granule organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process T cell secretory granule organizationISS:UniProtKB

Cytoplasmic granule
Cytolytic granule
Secreted, extracellular space
Golgi apparatus
Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity).
Secreted constitutively by endothelial cells and macrophages (PubMed:11154222).
Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585).

O-glycosylated; contains chondroitin sulfate and heparan sulfate.